Veterinary Drug Series - florfenicol

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1. Introduction

Florfenicol , also known as flumethammycin, is a commonly used veterinary antibiotic, with a wide antibacterial spectrum and strong antibacterial effect, it is a monofluorinated derivative of synthetic thionomycin, the molecular formula is C12H14Cl2FNO4S, white or off-white crystalline powder, odorless, very slightly soluble in water and chloroform, slightly soluble in glacial acetic acid, soluble in methanol and ethanol. It is a new broad-spectrum antibacterial drug of chloramphenicol class for veterinary medicine successfully developed in the late eighties.

 2. Indications

(1). Livestock: It is used for the prevention and treatment of asthma, infectious pleural pneumonia, atrophic rhinitis, swine lung disease, streptococcal disease, etc. caused by dyspnea, increased body temperature, coughing, choking, decreased feed intake, emaciation, etc., and is effective for E. coli and other piglets caused by yellow dysentery, enteritis, blood dysentery, edema, etc.

(2). Poultry: used for the prevention and treatment of cholera, chick dysentery, diarrhea, stubborn diarrhea, yellow-white and green stools, watery feces, diarrhea, intestinal mucosal punctate or diffuse bleeding, omphalis, heart, liver, bacteria, mycoplasma, etc. caused by chronic respiratory diseases, infectious rhinitis, air sac turbidity, cough, tracheal giggles, dyspnea, etc. caused by Escherichia coli, Salmonella, Pasteurium, etc.

(3). It has obvious effects on infectious serositis, Escherichia coli, Pseudomonas aeruginosa and so on in ducks.

3. Characteristics

(1). It has a very wide antibacterial spectrum, has a strong killing effect on Gram-positive bacteria and negative bacteria, and has a strong antibacterial effect on anaerobic Gram-positive bacteria and negative spirochetes, rickettsia, amoeba protozoa, etc.

(2). The antibacterial activity is significantly better than that of the current antibacterial drugs, such as: chloramphenicol, thiomycin, oxytetracycline, tetracycline and ampicillin, as well as the quinolones that are widely used at present.

(3). Fast-acting, the therapeutic concentration in the blood can be reached after 1 hour of florfenicol intramuscular injection, and the peak concentration of the drug can be reached in 1.5~3 hours; Long-acting, the effective blood concentration can be maintained for more than 20 hours with a single medication. 

(4). It can penetrate the blood-brain barrier and the therapeutic effect of bacterial meningitis in animals is not comparable with other antibacterial drugs.

(5). According to the recommended dosage, it has no toxic side effects, overcomes the risk of aplastic anemia caused by chloramphenicol and thiomycin and other toxicity, will not cause harm to animals and food, and is used for the treatment of infections in various parts of the body caused by bacteria, including the prevention and treatment of bacterial respiratory diseases, meningitis, pleurisy, mastitis, intestinal infections and postpartum syndrome in livestock.


4. Adverse reactions

(1). This product is toxic to embryos and is forbidden to be used in lactating and pregnant animals.

(2). This product does not cause aplastic anemia, but cattle may have adverse reactions such as transient anorexia, reduced water intake and diarrhea after medication.

(3). Inflammation may occur at the injection site.

(4). For others, see thiomycin.

(5). Drug withdrawal period:

Florfenicol powder - 20 days for pigs, 5 days for chickens, 375 degrees for fish, forbidden during the laying period;

Injections — cattle 28 days (intramuscular injection), cattle 38 days (subcutaneous injection), pigs 14 days, chickens 28 days, fish 375 degrees day.

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