Veterinary Drug Series - doramycin

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1. Introduction

Doramectin, CAS 117704-25-3.

It is a new generation of macrolide antiparasitic drugs, which is an avermectin antibiotic made by fermentation of a new strain of Streptomyces avidium through genetic recombinant cyclic hexanylic acid as a precursor, and is considered to be one of the best antiparasitic drugs in the avermectin family.

Compared with other ivermectin products, doramectin has high blood concentration, slow elimination, long maintenance time, more extensive anti-insect spectrum, no allergic reaction and other characteristics, which can be used as a good alternative to ivermectin antiparasitic drugs.

2. Pharmacological effects

White or white crystalline powder with very low solubility in water.

Doramectin is used to treat ectoparasitic diseases such as nematode disease and mite disease in livestock,

The main feature is that the blood concentration and half-life are higher or twice as long as ivermectin. The United States has approved injections for cattle and pigs and pourers for cattle.



3.Third, the use of effects

Doramectin is an internal and external parasite and an agent, which is effective against nematodes and arthropods. At present, the anthelmintic drugs commonly used in China's pig industry are: endoparasitic drugs: prothhimazole, levamisole, trichlorfon, viomycin, hygromycin, ivermectin, avermectin. Ectoparasitic drugs: trichlorfon, diamidamidine, diazinon, pyrethroids, avermectin, ivermectin.

Doramectin had a good effect on porcine digestive tract nematodes, and it was reported that pigs were administered intramuscularly at a dose of 0.3 mg/kg body weight, and the weight gain of artificial and natural infection cases was significantly higher than that of the control group at 7 days, 14 days and 2l days after administration (pig P<0.0001); Compared to the control group, the worms were 100% expelled without side effects. In the treatment of scabies mites, from suckling piglets to sows have good effects, after artificial infection with scabies mites, according to 0.3 mg/kg body weight intramuscular injection, after 4 weeks of testing, the results of skin inflammation, Chemicalbook damage and pig insect infection elimination effect is very obvious (P<0.05)。 In the treatment of kidney worms in pregnant sows, a one-time injection in the neck at a dose of 0.3 mg/kg was detected, and the detection rate of urine eggs was 0 and the expulsion rate was 100% on the 56th and 57th days, while the control group was 3762 eggs per milliliter of urine. It has the same effect on pig lung worms, pig lice, etc. The expiration date of the drug can be assessed based on the antiparasitic activity of tissues with antiparasitic activity greater than l ng/g. Concentrations of doramectin greater than 1 ng/g lasted for 26 days in the skin, 38 days in the lungs, 38 days in the gastrointestinal mucosa, and 38 days in the gastric mucosa. It can be seen that the time of doramectin in the mucosa and lung tissue of the digestive tract is greater than lng/g for 38 days, which is 20 days longer than ivermectin, so the repellent effect of doramectin on parasites is significantly stronger than that of ivermectin, and the effective time of preventing parasite reinfection is longer.

4. Precautions

1). The properties of doramectin are not very stable, and they are quickly decomposed and inactivated under sunlight, and their residual drugs are toxic to fish and aquatic organisms, so pay attention to water source protection.

2). Pouring agent: After the cattle are applied, it can not be rained within 6 hours.



3). Use with caution in dogs.

4). The operator should not eat or smoke when using this product, and wash his hands after operation.

5). Its residual drugs are toxic to fish and aquatic organisms, and attention should be paid to protecting water resources.

6). Withdrawal period, 35 days for cattle and 24 days for pigs.

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